Progestogens prevent the growth of the uterus linings during HRT. The use of progestogens protects the uterus inner lining against endometrial cancer compared to the use of oestrogens alone. Therefore, for women with an intact uterus a combination oestrogen/progestogen therapy should be used.
For women without a uterus, oestrogens alone should be used.
The progestogens used in HRT are entirely synthetic in origin and are therefore different from the progestogen that occurs naturally in women. But this difference results in additional positive properties, e.g. prevention of osteoporosis. Positive effects on bone mineral density have recently been shown for norethisterone acetate (NETA).5
Today, some experts believe it is biologically plausible that different progestogens might have different effects on the cardiovascular system.
APROM ID# 3079. May 2011.